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100%;max-width:100%;padding-left:15px;padding-right:15px;position:relative;width:100%}.download-block .download-block__download>div:not(:last-child){margin-bottom:3rem}@media (min-width:768px){.download-block .download-block__download>div{-webkit-box-flex:0;-ms-flex:0 0 50%;flex:0 0 50%;max-width:50%}.download-block .download-block__download>div:not(:last-child){margin-bottom:0}}.download-block p{line-height:1.3125rem;margin-left:auto;margin-right:auto;max-width:28.75rem}.download-block .btn{font-size:16px;font-size:1rem;line-height:1.1875rem;max-width:12.5rem;position:relative;text-align:left;width:100%}.download-block .btn:after{content:url(/themes/custom/knowvod/media/content/images/download-icon.svg);display:block;position:absolute;right:1rem;top:50%;-webkit-transform:translateY(-50%);-ms-transform:translateY(-50%);transform:translateY(-50%)}.download-block .btn span{display:block;text-transform:uppercase}.modal:before{background:rgba(0,0,0,.4);bottom:0;content:"";display:none;left:0;position:fixed;right:0;top:0;z-index:94037}.opened:before{display:block}.opened .modal-dialog{border:4px solid #b8cde6;top:40%;-webkit-transform:translate(-50%,-50%);-ms-transform:translate(-50%,-50%);transform:translate(-50%,-50%)}@media (min-width:576px){.opened .modal-dialog{top:45%}}.modal-dialog{box-align:center;-webkit-animation:fadein 1s;animation:fadein 1s;background:#fff;left:50%;position:fixed;text-align:center;top:-20%;-webkit-transform:translate(-50%,-500%);-ms-transform:translate(-50%,-500%);transform:translate(-50%,-500%);-webkit-transition:-webkit-transform 1s ease-out;transition:-webkit-transform 1s ease-out;-o-transition:transform 1s ease-out;transition:transform 1s ease-out;transition:transform 1s ease-out,-webkit-transform 1s ease-out;width:90%;z-index:94038}@media (min-width:576px){.modal-dialog{width:65%}}@media (min-width:992px){.modal-dialog{max-width:40.625rem}}@-webkit-keyframes fadein{0%{opacity:0}to{opacity:1}}@keyframes fadein{0%{opacity:0}to{opacity:1}}#interstitial2Modal .modal-header,#interstitialModal .modal-header{height:3.75rem}#interstitial2Modal .modal-header .close,#interstitialModal .modal-header .close{border:0;cursor:pointer;height:25px;margin-right:.9375rem;margin-top:.9375rem;opacity:1;-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);-webkit-transition:.5s ease-in-out;-o-transition:.5s ease-in-out;transition:.5s ease-in-out;width:25px}#interstitial2Modal .modal-header .close span,#interstitialModal .modal-header .close span{background:#d96d27;display:block;height:5px;left:0;opacity:1;position:absolute;-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);-webkit-transition:.25s ease-in-out;-o-transition:.25s ease-in-out;transition:.25s ease-in-out;width:100%}#interstitial2Modal .modal-header .close span:first-child,#interstitialModal .modal-header .close span:first-child{left:0;top:9px;-webkit-transform:rotate(45deg);-ms-transform:rotate(45deg);transform:rotate(45deg)}#interstitial2Modal .modal-header .close span:nth-child(2),#interstitialModal .modal-header .close span:nth-child(2){left:0;top:9px;-webkit-transform:rotate(-45deg);-ms-transform:rotate(-45deg);transform:rotate(-45deg)}#interstitial2Modal .modal-body,#interstitialModal .modal-body{padding:0 .9375rem 1.875rem}@media (min-width:768px){#interstitial2Modal .modal-body,#interstitialModal .modal-body{padding:0 60px 60px}}#interstitial2Modal .modal-body p,#interstitialModal .modal-body p{margin-left:auto;margin-right:auto;max-width:28.125rem}#interstitial2Modal .modal-body p:last-of-type,#interstitialModal .modal-body p:last-of-type{margin-bottom:.5rem}#interstitial2Modal .modal-body a,#interstitialModal .modal-body a{color:#fff;margin:1rem 1.5rem 0;padding:1rem 5.25rem}#interstitial2Modal .modal-body a:first-of-type,#interstitialModal .modal-body a:first-of-type{margin-bottom:2rem}@media (min-width:768px){#interstitial2Modal .modal-body a:first-of-type,#interstitialModal .modal-body a:first-of-type{margin-bottom:0}}#next-page{background:#d96d27;padding-bottom:1.125rem;padding-top:1.125rem;text-align:left}@media (min-width:992px){#next-page{padding-bottom:2.5rem;padding-top:2.5rem}#next-page .one-col-main{margin-left:66.66666667%}}#next-page .one-col-main>div{min-height:1.45rem}#next-page a{color:#fff;display:inline-block;font-size:16px;font-size:1rem;font-weight:700}@media (min-width:992px){#next-page a{max-width:18.125rem}}#next-page img{display:inline-block;margin-bottom:2px}#preloader{-webkit-box-pack:center;-ms-flex-pack:center;-webkit-box-align:center;-ms-flex-align:center;align-items:center;background-color:rgba(5,18,36,.8);bottom:0;display:-webkit-box;display:-ms-flexbox;display:flex;justify-content:center;left:0;position:fixed;right:0;top:0;z-index:1090}#preloader .loader{-webkit-animation:spin .75s linear infinite;animation:spin .75s linear infinite;border:4px solid rgba(217,109,39,.85);border-radius:50%;border-top-color:transparent;height:100px;width:100px}@-webkit-keyframes spin{0%{-webkit-transform:rotate(0deg);transform:rotate(0deg)}to{-webkit-transform:rotate(1turn);transform:rotate(1turn)}}@keyframes spin{0%{-webkit-transform:rotate(0deg);transform:rotate(0deg)}to{-webkit-transform:rotate(1turn);transform:rotate(1turn)}}[data-toggle=tooltip]{color:#467ab7;font-style:italic;font-weight:700;text-decoration:underline}.tooltip-inner{background:#e1e9f2;border-radius:0;color:#467ab7;font-size:16px;font-size:1rem;max-width:18.125rem;padding:.75rem 1rem;position:relative;text-align:left}.tooltip-inner:after,.tooltip-inner:before{bottom:0;-webkit-box-shadow:0 1px 6px rgba(0,0,0,.1);box-shadow:0 1px 6px rgba(0,0,0,.1);content:"";display:block;position:absolute;top:0;width:50%;z-index:-100}.tooltip-inner:before{left:0}.tooltip-inner:after{right:0}.bs-tooltip-auto[x-placement^=top] .arrow:before,.bs-tooltip-top .arrow:before{border-top-color:#e1e9f2}.bs-tooltip-auto[x-placement^=bottom] .arrow:before,.bs-tooltip-bottom .arrow:before{border-bottom-color:#e1e9f2}.tooltip.show{opacity:1}header{background:#d96d27;min-height:6.25rem;padding-bottom:3.75rem}@media (min-width:992px){header{padding-bottom:0}}#intended{color:#fff;font-size:11px;font-size:.6875rem;padding-bottom:2rem;padding-top:.75rem;text-align:center}@media (min-width:992px){#intended{padding-bottom:1rem;padding-top:1.25rem;text-align:right}}#intended p{font-size:11px;font-size:.6875rem;line-height:.9375rem;margin:0}#intended p span{display:block}@media screen and (min-width:375px){#intended p span{display:inline}}#intended .hcp-site{display:none}@media (min-width:992px){#intended .hcp-site{display:block}}#intended .hcp-site a{color:#fff;font-size:12px;font-size:.75rem;font-weight:400;padding-right:0}#intended .hcp-site a:after{vertical-align:middle}#logo{position:absolute;top:4.125rem;z-index:1}@media screen and (min-width:375px){#logo{top:3.125rem}}@media (min-width:992px){#logo{top:1.25rem}}#logo img{max-width:195px}@media (min-width:992px){#logo img{max-width:210px}}#site-branding .container{-webkit-box-pack:justify;-ms-flex-pack:justify;background:#fff;display:-webkit-box;display:-ms-flexbox;display:flex;justify-content:space-between;padding-bottom:.9375rem}@media (min-width:992px){#site-branding .container{padding-bottom:0}#site-branding nav .primary-gradient-block{display:none}}#menu-container{display:none;left:0;top:8.375rem;width:100%}@media screen and (min-width:375px){#menu-container{top:7.5rem}}@media (min-width:992px){#menu-container{background:transparent;border-bottom:0;display:-webkit-box!important;display:-ms-flexbox!important;display:flex!important;height:100%;margin-left:auto;margin-right:auto;top:auto}}#menu-primary{background:#fff;border-bottom:10px solid #d96d27;display:block;padding-left:.9375rem;padding-right:.9375rem}@media (min-width:992px){#menu-primary{-ms-flex-pack:distribute;background:none;border-bottom:none;display:-webkit-box;display:-ms-flexbox;display:flex;justify-content:space-around;max-width:none;padding-left:0;padding-right:0;width:100%}}#menu-primary .nav-item{background:#fff;width:100%}@media (min-width:992px){#menu-primary .nav-item{background:none;border-bottom:0;border-top:0;font-size:18px;font-size:1.125rem;width:auto}#menu-primary .nav-item:active .nav-link,#menu-primary .nav-item:focus .nav-link,#menu-primary .nav-item:hover .nav-link{border-bottom:.625rem solid #b8cde6}#menu-primary .nav-item:last-child{display:none}}#menu-primary .nav-item .nav-link{border-bottom:1px solid #979797;color:#467ab7;display:block;font-size:18px;font-size:1.125rem;font-weight:400;line-height:1.25rem;padding:1.25rem 0;text-align:left}@media (min-width:992px){#menu-primary .nav-item .nav-link{background:transparent;border-bottom:.625rem solid transparent;color:#fff;font-weight:500;margin-bottom:0;margin-left:0;margin-top:0;padding:.2rem 0;text-align:center;vertical-align:middle}#menu-primary .nav-item .nav-link:after{content:"";display:block;margin-left:-.625rem;margin-right:-.625rem}}#menu-primary .nav-item .nav-link svg{display:inline-block;position:relative;top:-2px}#menu-primary .nav-item .nav-link svg path{fill:#b8cde6}@media (min-width:992px){#menu-primary .nav-item .nav-link svg path{fill:#fff}}#menu-primary .nav-item:last-child .nav-link{border-bottom:none;color:#545454}@media (min-width:992px){#menu-primary .active .nav-link{border-bottom:.625rem solid #b8cde6}}footer{background:#e6e7ed;color:#545454;font-size:13px;font-size:.8125rem;padding-bottom:1.875rem}footer .container>div{display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;margin-left:-15px;margin-right:-15px}footer .container-fluid{background:#fff}footer .footer-menu{padding:2rem 15px;position:relative;width:100%}@media (min-width:576px){footer .footer-menu{padding-bottom:3.4375rem;padding-top:3.4375rem}}footer .footer-menu ul{-webkit-box-pack:center;-ms-flex-pack:center;display:block;justify-content:center}@media (min-width:576px){footer .footer-menu ul{display:-webkit-box;display:-ms-flexbox;display:flex}}footer .footer-menu ul li{text-align:center}footer .footer-menu ul li a{color:#545454;display:inline-block;font-size:14px;font-size:.875rem;padding-left:.5rem;padding-right:.5rem}footer .footer-menu ul li a:hover{text-decoration:underline}@media (min-width:992px){footer .footer-menu ul li a{padding-left:1rem;padding-right:1rem}}@media (min-width:576px){footer .footer-menu ul li:first-child a{padding-left:0}footer .footer-menu ul li:last-child a{padding-right:0}footer .footer-menu ul li:not(:first-child):before{color:#545454;content:" | ";margin-right:-.125rem}}footer #footer-logo{display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;margin:1.875rem -15px 1.5rem}@media (min-width:768px){footer #footer-logo{margin-bottom:2.5rem;margin-top:3.75rem}}footer #footer-logo>div{padding-left:15px;padding-right:15px;position:relative;width:100%}footer #footer-logo>div img{max-width:14rem}footer #copyright{display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;margin-left:-15px;margin-right:-15px}footer #copyright>div{padding-left:15px;padding-right:15px;position:relative;width:100%}@media (min-width:768px){footer #copyright>div{-webkit-box-flex:0;-ms-flex:0 0 50%;flex:0 0 50%;max-width:50%}}footer #copyright p{font-size:11px;font-size:.6875rem;margin-bottom:0}footer #copyright span:first-child{display:block}@media (min-width:768px){footer #copyright span{margin-bottom:0}footer #copyright span:first-child{display:inline-block}footer #copyright span:not(:first-child){margin-left:1rem}}#about .vod-body{margin-bottom:1.5rem}@media (min-width:768px){#about .vod-body{margin-top:2.25rem}}#about .vod-body .vod-body__image img{display:block;margin:0 auto;width:100%}@media (min-width:768px){#about .vod-body .vod-body__legend>div{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background-color:#f8ece7;display:-webkit-box;display:-ms-flexbox;display:flex;height:100%}}#about .vod-body .vod-body__legend>div>div{background-color:#f8ece7;display:block;margin:0 auto;padding:.75rem 0}#about .vod-body ol{counter-reset:vod-body-counter;list-style:none;margin:0 auto;max-width:6.25rem}@media (min-width:768px){#about .vod-body ol{max-width:none}}#about .vod-body ol li{color:#4a4a4a;counter-increment:vod-body-counter;font-weight:700;margin-bottom:1rem;position:relative}#about .vod-body ol li:last-child{margin-bottom:0}@media (min-width:768px){#about .vod-body ol li{font-size:24px;font-size:1.5rem;margin-bottom:3rem}}#about .vod-body ol li:before{border:2px solid #4a4a4a;border-radius:50%;color:#4a4a4a;content:counter(vod-body-counter);font-size:14px;font-size:.875rem;font-weight:700;height:1.5rem;left:-54%;position:absolute;text-align:center;top:0;width:1.5rem}@media (min-width:768px){#about .vod-body ol li:before{font-size:24px;font-size:1.5rem;height:2.75rem;padding:.1875rem;top:-.3125rem;width:2.75rem}}#signs-and-symptoms .intro-section{padding-bottom:1rem}#signs-and-symptoms .symptoms{margin-top:2rem}#signs-and-symptoms .symptom img{display:block;margin:0 auto .625rem}#signs-and-symptoms .symptom p{text-align:center}#signs-and-symptoms .symptom:not(:last-child){margin-bottom:1rem}#signs-and-symptoms .other-signs-section{background:#e1e9f2;margin-bottom:1rem;padding:2.25rem 0}#signs-and-symptoms .other-sign{margin-bottom:2rem}#signs-and-symptoms .other-sign img{display:block;margin:0 auto .625rem}#signs-and-symptoms .other-sign p{text-align:center}#signs-and-symptoms .footnote{margin:0 auto;max-width:36.25rem}#signs-and-symptoms .footnote p{font-size:14px;font-size:.875rem;line-height:1.5}@media (min-width:768px){#signs-and-symptoms .footnote p{text-align:center}}#signs-and-symptoms .vod-effects-section{background:#f8ece7;margin-bottom:1.5rem}@media (min-width:768px){#signs-and-symptoms .vod-effects-section{margin-bottom:3.75rem}}#signs-and-symptoms .vod-effect{margin-bottom:2rem}#signs-and-symptoms .vod-effect img{margin-bottom:1rem;width:100%}#signs-and-symptoms .vod-effect p{margin-bottom:1rem}#risk-factors .risk-factors p{font-weight:500}#risk-factors .child-risk-factors-section{background:#e1e9f2;padding:2rem 0 0}#risk-factors .child-risk-factors-section h2{color:#7a7a7a;font-size:20px;font-size:1.25rem;margin-bottom:1.5rem}#risk-factors .child-risk-factors-section p{font-weight:500}#risk-factors .child-risk-factors-section .child-risk-factors{-webkit-box-orient:vertical;-webkit-box-direction:normal;-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-flow:column nowrap;flex-flow:column nowrap}@media (min-width:768px){#risk-factors .child-risk-factors-section .child-risk-factors{-webkit-box-orient:horizontal;-webkit-box-direction:normal;-webkit-box-align:stretch;-ms-flex-align:stretch;align-items:stretch;-ms-flex-direction:row;flex-direction:row}}#risk-factors .child-risk-factors-section .icon-wrapper{margin-bottom:1rem}@media (min-width:768px){#risk-factors .child-risk-factors-section .icon-wrapper{-webkit-box-flex:0;-ms-flex:0 0 4.0625rem;flex:0 0 4.0625rem}#risk-factors .child-risk-factors-section .copy-wrapper{-webkit-box-flex:1;-ms-flex:1 0 100%;flex:1 0 100%;margin-left:1.125rem;max-width:28.125rem}}#monitoring .transplant-team__list-row{display:-webkit-box;display:-ms-flexbox;display:flex;-ms-flex-wrap:wrap;flex-wrap:wrap;margin-left:-15px;margin-right:-15px}#monitoring .transplant-team__list-col{-webkit-box-flex:0;-ms-flex:0 0 100%;flex:0 0 100%;max-width:100%;padding-left:15px;padding-right:15px;position:relative;width:100%}#monitoring .transplant-team__list-col:first-of-type ul{margin-bottom:.25rem}@media (min-width:768px){#monitoring .transplant-team__list-col{-webkit-box-flex:0;-ms-flex:0 0 50%;flex:0 0 50%;max-width:50%}}#monitoring .transplant-signs-section{background:#e1e9f2;margin-bottom:1.5rem;padding:2rem 0 .5rem}@media (min-width:768px){#monitoring .transplant-signs-section{margin-bottom:2.25rem}#monitoring .transplant-signs{margin-top:3rem}}#monitoring .transplant-sign{margin-bottom:3rem}#monitoring .transplant-sign img{display:block;margin:0 auto .625rem}#monitoring .transplant-sign p{text-align:center}#glossary .glossary{padding-top:2rem}@media (min-width:768px){#glossary .glossary{padding-top:3.75rem}}#glossary .h2{margin-bottom:1.5rem}#glossary dd,#glossary dt{font-size:18px;font-size:1.125rem;line-height:1.2}#glossary dd p,#glossary dt p{line-height:1.2;margin:0}#glossary dt{font-weight:500;margin-bottom:.5rem}#glossary dd:not(:last-child){border-bottom:.0625rem solid #7a7a7a;margin-bottom:1.75rem;padding-bottom:1.75rem}#site-map .site-map{padding-bottom:2rem;padding-top:2rem}@media (min-width:768px){#site-map .site-map{padding-top:3.75rem}}#site-map .h2{margin-bottom:1.5rem}#site-map ul{padding-left:0}#site-map ul li{color:#467ab7}#site-map ul a{color:#467ab7;font-size:18px;font-size:1.125rem;font-weight:500;padding:0}