You are using an outdated browser. Please upgrade your browser to improve your experience and security.

Skip to content


Understanding VOD of the liver

What is VOD (also known as SOS)?

Hepatic veno-occlusive disease (VOD) is a complication that affects the liver and can occur following stem-cell transplant. VOD may also be referred to as sinusoidal obstruction syndrome, or SOS, by the transplant team.

VOD begins in the liver and can quickly affect other vital organs, most notably the kidneys and lungs.

When VOD is identified, it requires immediate medical attention, as it can rapidly worsen.

Representation of the lungs, liver, and kidneys within the abdomen.
  1. Lungs
  2. Liver
  3. Kidneys

What causes VOD?

VOD is thought to be caused by certain treatments given to prepare the bone marrow for stem-cell transplant.

Treatments given to prepare the bone marrow for stem-cell transplant are called conditioning regimens and may include chemotherapy or radiation.

These treatments can damage cells in the liver, leading to a blockage that can reduce blood flow in the liver. This can cause changes throughout the body.

Downloadable guide to VOD

Print a brochure with information on VOD to share or keep for reference.

The content on this site is not intended to replace a conversation with your transplant team. Only a trained healthcare professional can evaluate your symptoms and make a diagnosis.